WebFeb 19, 2024 · The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A … WebApr 15, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4′-phosphopantetheine, yielding dephospho-CoA (dPCoA). Each phosphopantetheine adenylyltransferase (PPAT) subunit displays a dinucleotide …
Purification and Characterization of Phosphopantetheine ...
WebJan 25, 2002 · Introduction. Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an adenylyl group from ATP to 4′-phosphopantetheine (Ppant), which yields 3′-dephospho-CoA (dPCoA) and pyrophosphate. 2 CoA biosynthesis occurs in a series of … WebJun 3, 2010 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pathway, reversibly transferring an adenylyl group from ATP to 4'-phosphopantetheine (PhP) to form dephosphocoenzyme A. This reaction sits at the branch point between the de novo pathway and the salvage pathway, and has been … scan of newtown ct
A Novel Adenylate Binding Site Confers …
WebMar 25, 2024 · Abstract Crystals of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis (PPATMt), which were grown using 2-methyl-2,4-pentanediol (MPD) or ammonium sulfate as the precipitant, belong to sp. grs. R32 and Р32, respectively. Crystals of the enzyme containing the ligand in the active site were obtained by the … WebMar 20, 2024 · Crystal structure of the complex of phospho pantetheine adenylyl transferase from Acinetobacter baumannii with two ascorbic acid (Vitamin-C) molecules. PDB DOI: 10.2210/pdb6JOG/pdb Classification: TRANSFERASE Organism (s): Acinetobacter baumannii Expression System: Escherichia coli Mutation (s): No Deposited: 2024-03-20 … WebJan 18, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by … scan of northern va