Phoslactomycins
WebFeb 21, 2024 · Phoslactomycins [ 10, 11, 12, 13] and leustroducsins [ 14, 15] are polyketides that possess α,β-unsaturated δ-lactone and cyclohexane moieties at both ends, which are tethered through a highly unsaturated chain with a phosphate ester. WebOct 6, 2024 · Miniaturized cultivation profiling (MATRIX) established optimal conditions for the production, isolation, and identification of the polyketide δ-lactone phoslactomycin E (1) and new ester...
Phoslactomycins
Did you know?
WebPhoslactomycin B C25H40NO8P CID 11497184 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... WebA Convergent Approach toward the C1−C11 Subunit of Phoslactomycins and Formal Synthesis of Phoslactomycin B. Organic Letters, 11(4), 935–938. doi:10.1021/ol8029142 .
WebJun 12, 2009 · Phoslactomycins (PLMs), biosynthesized using a cyclohexanecarboxylic acid as the starter unit [5], [6], were isolated as antifungal antibiotics [7], [8], [9], [10] (Fig. 1A). Previously, we reported that PLMs are potent Ser/Thr phosphatase 2A (PP2A) inhibitors in vitro and in vivo [11], [12]. WebAug 21, 2008 · The antifungal phoslactomycins (PLM A-F), produced by Streptomyes sp. HK803, are structurally unusual in that three of their four double bonds are in the cis form (Δ 12,13, Δ 14,15, Δ 2,3 ).
WebFeb 21, 2024 · Phoslactomycins [ 10, 11, 12, 13] and leustroducsins [ 14, 15] are polyketides that possess α,β-unsaturated δ-lactone and cyclohexane moieties at both ends, which are tethered through a highly unsaturated chain with a phosphate ester. WebA general methodology applicable for the synthesis of the phoslactomycin family of antibiotics, potent and selective protein phosphatase inhibitors, has been developed starting from a β-isocupreidine-catalyzed asymmetric Baylis–Hillman reaction of 3- (4-methoxybenzyloxy)propanal with hexafluoroisopropyl acrylate, and thereby formal …
Webbiological activities of phoslactomycins (PLMs) and re-lated compounds (Fig. 1) and the current status of our work on genetic manipulation of the biosynthetic pro-cess. …
WebAbstract. (+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki−Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Δ 12 ... how does a firestick work on my tvWebProtein phosphorylation is a key regulatory mechanism of the organization and dynamics of the actin cytoskeleton during cell motility, differentiation, and cytokinesis. The level of … how does a firewall protect dataWebProlactin (also known as lactotropin and PRL) is a hormone that’s responsible for lactation, certain breast tissue development and contributes to hundreds of other bodily processes. … how does a firewall protect a computerWebSep 15, 2003 · Phoslactomycins (PLMs) A–F, produced by actinomycetes are polyketide-type antibiotics derived from a hydroxycyclohexanecarboxylic acid or a … how does a firework actually workWebMay 5, 2006 · The implicated intermediate in the biosynthesis of phospholine (phoslactomycin B, see picture), namely its deamino precursor, as well as phospholine itself are synthesized. The phoslactomycins show antitumor, antibacterial, and antifungal activities, however, it is not yet known which part of the skeleton contributes to the … phophi ramathuba ageWebNov 10, 2012 · Phoslactomycins (PLMs) are inhibitors of protein serine/threonine phosphatase 2A showing diverse and important antifungal, antibacterial and antitumor … how does a firewall operateWebDec 1, 2016 · Streptomyces kronopolitis sp. nov., an actinomycete that produces phoslactomycins isolated from a millipede (Kronopolites svenhedind Verhoeff) Chongxi Liu 1 ,†, Lan Ye 1 ,†, Yao Li 1 , Shanwen Jiang 1 , Hui Liu 1 , Kai Yan 1 , Wensheng Xiang 1 ,2 , Xiangjing Wang 1 how does a firewall works