Cisplatin potassium wasting

Author: mxfy

August undefined, 2024

WebOne way your body regulates blood potassium levels is by shifting potassium into and out of cells. When there is a breakdown or destruction of cells, the electrolyte potassium moves from inside of the cell to outside of the cell wall. This shift of potassium outside of the cells causes hyperkalemia. WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as …

Differential diagnosis of hyponatremia induced by cisplatin …

WebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, … WebDec 13, 2024 · The electrolytes affected are primarily mineral ions, specifically potassium, calcium, magnesium, sodium, and chloride. Fundamentally, like Bartter’s syndrome, Gitelman syndrome is a salt wasting nephropathy. The symptoms and severity of the disorder can vary greatly from one person to another and can range from mild to severe. early man to modern man

Gitelman Syndrome - Symptoms, Causes, Treatment NORD

Webis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion … WebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … c++ strings mutable

Cisplatin dosing, indications, interactions, adverse effects

Effect of Silymarin Administration on Cisplatin Nephrotoxicity: …

WebMar 1, 2024 · cisplatin cyclosporine duloxetine lithium methotrexate methylphenidate NSAIDs, such as diclofenac, ibuprofen, or indomethacin sucralfate other medications that lower potassium. People taking oral medications for diabetes may need to talk to their doctor about adjusting the dose of their medicine. Webbular dysfunction with sodium, potassium, and magne-sium wasting. Most patients have a reversible decrease in glomerular filtration, but some have an irreversible de- ... Cisplatin is accumulated by peritubular uptake in both the proximal and … cstring spanincludingWebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and urinary magnesium and potassium wasting increased significantly after cisplatin infusion in … c# string split

"WebCDDP-induced hyponatremia has also occurred in a case of renal salt-wasting syndrome, 4 in patients with nausea/vomiting/anorexia, and when vigorous hydration was administered to prevent nephrotoxicity. 5 It is sometimes difficult to accurately diagnose the cause of hyponatremia because various contributing factors can interact in a complex manner. " - Cisplatin potassium wasting

Cisplatin potassium wasting

Hypomagnesemia and renal magnesium wasting in patients …

WebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85 WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article …

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WebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. Web42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high …

WebCisplatin Foscarnet Aminoglycosides: Laxatives/enemas Sodium polystyrene sulfonate: ... Renal potassium wasting is indicated by a 24-hour urine potassium level exceeding 15 to 30 mEq per L. WebDifferential diagnosis of hyponatremia induced by cisplatin-containing chemotherapy: syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or renal salt wasting syndrome (RSWS) Mari Inamori , Hidenori Inohara & Arata Horii Pages 33-35 Received 01 Apr 2016, Accepted 29 May 2016, Published online: 10 Sep 2016 Download citation

WebOct 5, 2014 · 1. Introduction. Cisplatin (CAS No. 15663-27-1, MF-Cl 2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry.It is a white or deep yellow to yellow-orange crystalline powder at room temperature. It is slightly soluble in water and soluble … WebThe urinary potassium excretion of a patient with hypokalemia is lowered to less than 25 mEq/day. 35 A value above this suggests at least a component of renal potassium wasting. Because 24-hour urine collections are often impractical, a spot urine potassium may be performed.

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … early man release dateWebJul 2, 1992 · Cisplatin has many toxic effects; emesis, impairment of renal function, myelosuppression, peripheral neuropathy, ototoxicity and renal tubular wasting. We used MVP regimen (Mitomycin C, Vp-16, and Cisplatin) in advanced Non-Small Cell Lung Cancer (NSCLC). c# string split by commaWebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … c++ string split boostWebwasting due to cisplatin therapy. Although patients with cancer have hyponatremia due to many etiologies (Table 1), SIADH is the most common etiol-ogy that is directly … early maori cheifsWebJul 20, 2024 · Since platinum agents are nephrotoxic, emetogenic and diarrheagenic, they have the potential to induce potassium wasting … cstring size c++c# string split by characterWebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal … c# string split by string