WebJan 21, 2016 · In the validation data set, which included 314 patients, the rate of 5-year disease-free survival was lower among the 38 patients (12.1%) with CDX2 protein–negative colon cancers than among the ... WebBackground: Survival of metastatic colorectal cancer (mCRC) patients has improved, but mainly for trial patients. New predictive and prognostic biomarkers validated in the general mCRC population are needed. Caudal-type homeobox 2 (CDX2) is an intestine-specific transcription factor with potential prognostic and predictive effect, but the importance in …
CDX2 Expression in Primary and Metastatic Prostatic …
WebNov 2, 2010 · CDX2. Synonyms. CDX3. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo. … WebCDX2; caudal type homeobox 2: Aliases: CDX3, CDX-3, CDX2/AS : Location: 13q12.2: Summary: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic ... is arise worth it
CDX2 Expression in Primary and Metastatic Prostatic Adenocarcinoma…
WebJan 29, 2014 · Introduction. CDX2 is a homeobox domain-containing transcription factor that plays an important role in intestinal development by regulating the proliferation and differentiation of intestinal cells , , .CDX2 … WebOct 28, 2024 · CDX2 encodes a transcription factor expressed in the nuclei of intestinal epithelial cells. The CDX2 immunohistochemical stain has excellent diagnostic utility in the setting of carcinoma of unknown primary, especially in combination with cytokeratins 7 and 20. While the stain is fairly specific for intestinal origin, it is also expressed in ... WebNov 26, 2024 · CDX2 expression is absent in ~30% of human CRC and is inversely associated with tumour grade. 25,26 Mice with a CDX2 +/− genotype are susceptible to … omicron symptoms that linger